Postdoctoral Fellow

 •  University Health Network Toronto, ON

Misc. Healthcare

Salary depends on experience
Posted on 12/11/17
Misc. Healthcare
Salary depends on experience
Posted on 12/11/17

The Advanced Molecular Diagnostics Laboratory at the Princess Margaret Cancer Center is a unique translational laboratory with the goal of developing and bringing to clinical molecular diagnostic use new genomic technologies for improved cancer care.

As an integral member of the Advanced Molecular Diagnostics Laboratory’s Variant Interpretation Group, the responsibilities of the Interpretation and Curation Specialist include: utilizing software tools, databases and primary literature to investigate the clinical relevance of next-generation sequencing (NGS)-detected variants; drafting variant annotations; utilizing practical and theoretical knowledge for the analysis of NGS data, including somatic and germline testing using multiple NGS molecular profiling platforms and methodologies; completing required laboratory database and reporting activities related to variant analyses; and gathering pertinent clinical data from the medical record to assist in NGS analysis.

Other duties include completing assigned workload in a manner to ensure the efficient operation of the laboratory; participating in molecular profiling test development activities with laboratory technologists, as required; maintaining quality control standards in assigned area; participating in communication activities to maintain and continually enhance the co-operation and coordination of services with other laboratory staff and with external lab clients; participating in professional development, teaching/education activities, safety and quality improvement programs to ensure excellence in the provision of services; adhering to Hospital and departmental mission and value statements while maintaining patient confidentiality; performing cross-functional duties as assigned, or requested; performing other duties related to and consistent with the job classification, as required.


• Completion of a recognized Doctor of Philosophy (PhD) program in Molecular Genetics or related discipline
• Current experience in NGS analysis preferred
• Experience in molecular genetic variant assessment techniques essential
• Experience with the use of genetic databases/resources and software (e.g., COSMIC, IGV, Alamut) is essential
• Knowledge of and experience with the theory and application of NGS platforms an asset
• Must be willing to perform “on call” duty as required by the laboratory
• Knowledge of the theory and practice of current NGS laboratory procedures, instruments, equipment and special techniques
• Excellent problem recognition and problem-solving skills
• Effective organizational, time management and prioritization skills
• Excellent verbal and written communication skills
• Ability to work independently and accurately under stressful conditions
• Ability to work effectively as a team member
• Understanding of appropriate behaviour required to work successfully in a diverse work group
• Knowledge of applicable Hospital and departmental policies, procedures, guidelines, protocols and practices
• Must be computer literate in Windows based applications
• Demonstrated interest in continuing education

JOB POSTING # 814695

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