Kansas City, MO
Not Specified years
Posted 186 days ago
Some small molecule drugs cause idiosyncratic adverse drug reactions (IADRs). One potential mechanistic hypothesis for IADRs is that they are an immune response to covalent modification of proteins by drugs or their metabolites. Our group is interested in the combined antibiotic, trimethoprim-sulfamethoxazole, as it is frequently prescribed and is associated with a high rate of IADRs. The focus of our translational research project is to identify and quantify proteins that are modified by small molecule drugs in cell lines, human liver microsomes, and in patient plasma/serum samples. The second part of this project is the detection and quantification of immunologic markers associated with IADRs including anti-drug antibodies.
We are looking for a highly motivated individual with a strong background in protein biochemistry and immunological techniques. Expertise in molecular biology techniques including immunoprecipitation, western blotting, protein purification, and ELISA is required. A background in cell biology would be preferred. Experience with immunology or mass spectrometry is welcomed. A qualified applicant will work as part of a team physician-scientists, research technicians and PhD scientists. Opportunities to attend didactics in pediatric clinical pharmacology are available.