Industry: Hospitals & Medical Centers•
Not Specified years
Posted 64 days ago
Schedule: Full Time
Hours: 8:30 A-5P
Location: Tufts Medical Center
We have an opening for a Post-doctoral Fellow to work in the field of Protease Signaling and Metabolism in the Center for Hemostasis and Thrombosis Research at Tufts Medical Center.
Under the direction of Dr. Athan Kuliopulos, the candidate will have the opportunity to conduct state-of-art research in metabolism using our newly developed conditional Protease-activated receptor (PAR)-knock-out mice. The candidate will work primarily on a project involving protease-G protein coupled receptor signaling in cells in the liver and other tissues, employing their skills in signal transduction assays and cell and molecular biology, in addition to animal models. There are three areas of research that the postdoc will be involved in. One is to determine how PAR2 regulates metabolism and inflammation in the context of high-fat diet and diabetes models. The second is to determine the effect of PAR2 levels and related biomarkers in patient samples obtained from our clinical trials in subjects with non-alcoholic steatohepatitis (NASH) and other metabolic diseases. Thirdly, cell-penetrating pepducin technology, pioneered in the Kuliopulos lab, will be employed in various state-of-the art mouse models, and in patients undergoing treatment with a first-in-class PAR2 pepducin. The postdoc will spearhead the design and execution of all experiments, as well as their interpretation.
Ph.D. and/or M.D.
The position requires excellent quantitative and analytical skills and experience with tissue culture techniques and biochemistry/signal transduction. Applicants with a strong background in animal models or metabolism are preferred.