As the immunologicalexpert who strategically supports development of both Oncosec’s IND pipeline as well as the clinical immune monitoring/biomarker program, the Director of Translational Biology is responsible for leading a dynamic group of scientists, research associates and technicians focused on pre-clinical in vivoexperiments and immune-based analyses of clinical biomaterials. Responsible for defining, designing and implementing a pre-clinical program to develop and understand relevant mechanisms underlying Oncosec’s preclinical immunotherapeutic pipeline to deliver an IND candidate. Additionally, the Director will continue to evolve Oncosec’s biomarker and immune monitoring program to support all clinical trials.
This position is responsible for taking the lead inthe development of publications arising from these studiesand other relevant initiatives. To execute these objective, the Director will need to identify and manage external vendors, project budgets and project timelines, ensuring all the project requirements and/or objectives are correctly gathered, understood by all team members and properly translated for execution.
The Director of Translational Biology remains current with medical developments and relevant immuno-oncology publications,applyingthis knowledge to Oncosec’s relevantprograms. Additionally, he/she will combine market awareness with scientific expertise to cross-functionally interact with internal (BD/IR) and external colleagues(investor/collaborator/KOL). ESSENTIAL JOB DUTIES/RESPONSIBILITIES:
•Collaborates withacademic investigators, industry providers,Bio-Engineering and Research & Development groups to effectively supporta portfolio of oncology and non-oncology assets across the R&D-Clinicalcontinuum•Directs in vivo/ex vivotranslational research frompreclinical proof-of-concept experiments to detailed mechanism of action investigations to support Oncosec’s immunotherapeutic pipeline and/or deliver an IND
•Managesand coordinatesin vivo immunology and clinical science group activitiesto meet specified departmental/corporate goals and timeframes•Manages development of assaysrelated to non-clinical/CMC andclinical studies•Identifies, develops and implements biomarker workflowsfor patient selection, immune mechanism of actionand PD/safety assessments in clinical study protocols, adheringto pre-specified timelines, budget and performance standards•Oversees patient sample analyses and coordination of data generation, integration, and communication internally as well as externally in high impact journal and meetings•Works with cross functional teams including internal team members and external vendors, and provides guidance and motivation to achieve milestones
•Manages external vendors including defining project requirements, tracking performance, and reviewing/approving invoices•Balancesthe cost, schedule and time frames against project requirements•Maintains a command of relevant scientific literature and evaluates implications for internal projects•Contributesto the management and writing of scientific documents including manuscripts,
research protocols and corporate related communications •Assists Regulatory Affairs to ensure the timely preparation of documents to be submitted to the FDA and other health authorities for review•Definesproject requirements and documentstechnical and financial progress to key stakeholdersthrough both oral and formal written reports
•Generates and managesoperational budgets and finance reporting•Manages direct reports and leadsmatrix teams of cross functional members as neededEDUCATION/EXPERIENCE/SKILLS:
•Ph.D. degree in immunology or a related study with 12years of experience in a combination of the following required areas:?Translational and/or clinical immunology research ?Relevant industry experiencein pre-clinical immuno-oncology ?Experience in cancer biology, with a particular emphasis on tumor immunology?Track record of scientific presentationsat conferences, academic and internal company seminars?Progressively increasing experience leading and managing research teamsMust possess:
•Proficiencyat supporting effective interactions between team members and among cross-functional teams•Demonstrated ability to multi-task work assignments and intellectual dexterity to grasp new concepts/changing ideas•Proven ability to quickly troubleshoot immune-based models;define what needs to be solved and determine the appropriate next steps.
•Able toeffectively share information and ideas within and outside of department in written or verbal form; able to put forth own ideas and gain understanding from others.
•Skills as a poised and knowledgeable presenter of scientific information. This includes excellent writing capabilities and strong demonstrated presentation skills, including presentations within external formats such as physician gatherings, medical congresses, etc.•Adept at Microsoft Office applications and GraphPad Prismfor data analysis•Ability to work outside of normal business hours including weekend work as required.
•Ability to travel both domestically and internationally up to 25% as required.•We are interested in every qualified candidate who is eligible to work in the United States. However, we are not able to sponsor visas