Industry: Professional, Scientific & Technical Services•
8 - 10 years
Posted 61 days ago
Daiichi Sankyo Cancer Enterprise has a bold ambition to become a leading world- class organization in oncology based on 3 pillars: Antibody-Drug Conjugates (ADC), AML and Breakthrough Science. To that end, we are looking for Translational Science leaders to help us quickly progress our new medicines from Discovery through clinical development and to registration.
U3-1402 is a human epidermal growth factor receptor 3 (HER3)-targeting ADC of high drug-to-antibody-ratio (DAR: 7 to 8) with a novel linker and topoisomerase I inhibitor payload. HER3 is overexpressed in a variety of cancers, including breast, lung, colorectal, ovarian, prostate and urothelial cancer. In an ongoing Phase I clinical trial in patients with HER3 expressing metastatic breast cancer, U3-1402 has shown significant clinical benefit with a manageable safety profile. However, as the drug may benefit a number of additional patients, a global clinical translational development plan must be defined and managed to help these patients withunmet medical need.
This newly created position will be responsible for creating the strategy and will have programmatic responsibility for the Translational Science (TS) plan that will be incorporated into the U3-1402 drug development program. The TS plan will include all aspects of pharmacodynamic and clinical biomarkers, companion diagnostics and nonclinical biology research needed to inform development decisions throughout the development life-cycle. The selected candidate will report to the Global Head of Oncology Translational Development.
The candidate will work in collaboration with other members of global Daiichi Sankyo functional areas including preclinical research, biomarker research (BM/CDx/Ops),
CDx development, safety, clinical pharmacology, and global clinical development. The candidate will be a core member of the global program team and, depending on their potential and experience, lead the global translational sciences subteam.
Close interaction with global functions in Japan, US and Europe will be a key part of this job, as well as developing and maintaining strong collaborations and relations with external top scientists and physicians (including representing DS at key congresses and meetings).
This position is based in Basking Ridge, NJ; Travel expected to be ~ 30%
Experience and Required Skills
Compensation and seniority level/title will be commensurate with experience and qualifications. Duties and responsibilities may vary based on the position level/title.Daiichi Sankyo, Inc., is an equal opportunity/affirmative action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected veteran status, age, or any other characteristic protected by law.