Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on targeted RNA delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety.
Our employees are nimble, science-driven, innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics in a variety of indications to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, toxicology and manufacturing.
Madison, WI is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations.
The Director, Medicinal Chemistry will be a key member of the drug discovery team at Arrowhead’s Madison, WI-based Research & Development facility and will lead multiple internal and/or partnered drug discovery programs based on the company’s RNAi-based platform technology. The candidate will contribute to overall drug discovery strategy and pipeline prioritization and will drive medicinal chemistry strategy. Significant experience with structure-based drug design, research project management and track record of developing candidates to enter the clinic is desired.