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Computational Chemist, Small Molecule Drug Discovery in South San Francisco, CA



$80K - $100K*


Life Sciences


Less than 5 years

Job Description

The Position

The Computational Drug Discovery group is seeking a computational scientist interested in applying state-of-the-art structure-based drug design, ligand-based design, and cheminformatics to discover novel small-molecule drugs for life-affecting diseases. You will be an integral member of interdisciplinary drug discovery project teams, where you will apply molecular modeling and data-mining to help drive lead discovery, optimization, and development. You will also be involved in helping to improve our "best of breed" infrastructure of computational chemistry and cheminformatics software and workflows. You will work closely with our Chemistry, Structural Biology, High Throughput Screening, DMPK, Safety/Investigational Toxicity, and other groups. You will have access to state of the art hardware, software, and infrastructure support in a fast-paced and creative environment. Based in our beautiful South San Francisco campus, you will join our team of computational ch

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Valid through: 2020-4-3

About Genentech

Genentech, Inc., is a biotechnology corporation which became a subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within Roche. As of August 2015, Genentech employed 13,720 people. The company was founded in 1976 by venture capitalist Robert A. Swanson and biochemist Herbert Boyer. Boyer is considered to be a pioneer in the field of recombinant DNA technology. In 1973, Boyer and his colleague Stanley Norman Cohen demonstrated that restriction enzymes could be used as "scissors" to cut DNA fragments of interest from one source, to be ligated into a similarly cut plasmid vector. While Cohen returned to the laboratory in academia, Swanson contacted Boyer to found the company. Boyer worked with Arthur Riggs and Keiichi Itakura from the Beckman Research Institute, and the group became the first to successfully express a human gene in bacteria when they produced the hormone somatostatin in 1977. David Goeddel and Dennis Kleid were then added to the group, and contributed to its success with synthetic human insulin in 1978.
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