Clinical and Translational Imaging Expert, BioMarker Development
The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. NIBR includes about 6500 associates across 7 locations worldwide. Translational Medicine (TM) is the clinical research arm of NIBR, and includes about 1000 associates globally. TM plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, and bridging drug discovery and clinical application. The Biomarker Development Department works in partnership with Novartis and external translational biologists, physicians and companies to develop precision medicines for all stages of clinical development by applying state of the art imaging, proteomic, genetic, genomic, cellular and computational approaches which address clinical and biological pathway questions.
The Biomarker Development (BMD) group, at the Novartis Institutes for BioMedical Research (NIBR), is seeking an Imaging Expert to join our dynamic Clinical and Translational Imaging (CTI) team and actively provide strategic, scientific, technical expertise and leadership on the optimal use of imaging in drug development. This is a unique opportunity to be part of a translational imaging department with deep expertise in structural and molecular imaging biomarkers and with broad impact from preclinic to clinic.
The CTI group in East Hanover enables in vivo imaging with a focus on MR, CT, OCT, RCM, ultrasound, and thermal imaging. The team is a key resource for our global imaging group to develop and validate novel imaging technologies (devices, software, algorithms) and readouts. The goal of the laboratory is to translate/reverse translate innovative tools into/from the clinic. Candidates must exhibit a strong scientific ability and proven expertise in the areas of translational imaging applications.
The role will be responsible for leading translational (in man and in model systems) imaging studies internally and externally, using primarily MR and CT imaging although other novel imaging modalities may be used. This role is will provide key imaging expertise in one or several modalities for proof-of-concept clinical trials to enable fit-for-purpose imaging strategy and timely execution of the imaging readouts for drug development decisions. The role will identify and/or develop novel imaging techniques by performing or managing data acquisition and analysis, providing result interpretation and presenting results to multidisciplinary teams. Moreover, the candidate will help support the management and workflow of CTI’s internal imaging PACS database. The candidate will work both independently and collaboratively with colleagues in BMD as well as other groups as a member of cross-functional teams (including NIBR clinical teams, Disease Areas, Pathology, Preclinical Safety department and external collaborators).
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• PhD degree in Biomedical, Biophysics or Engineering or related field in the biomedical sciences (biology/biophysics/chemistry).
• Experience with hands-on in vivo small animal imaging, preferably with multiple imaging modalities (MRI, CT, PET, ultrasound and/or optical imaging). A strong expertise in preclinical and/or clinical MR imaging for various applications is required
• Capability and interest to learn new modalities, such as computed tomography or optical imaging
• Deep understanding of image acquisition and artifacts across modalities
• Knowledge of translational studies in drug development required
• Ability to manage image data formats across imaging devices (MRI, CT, US) and vendors to ensure no bottlenecks in clinical data workflow
• Minimum 3+ yrs of experience with image analysis software (Image J, Analyze, Osirix…etc), algorithm development (MatLab , C++) and use of image processing tools (segmentation, erosion, dilation, 3D rendering etc) is required
• Fluency in English (written and spoken) is a must
• Flexibility and ability to work on a team, comfortable with multitasking, excellent interpersonal skills to communicate and collaborate in a multi-disciplinary environment, willingness to take on additional responsibilities
• Excellent project management and presentation skills