Merrimack is looking for a highly motivated postdoc with an interest and experience in cancer pharmacology and tumor biology to join an interdisciplinary team that develops innovative new drug candidates, including those that engage the immune system to fight cancer. We are looking for a candidate who thrives in an interdisciplinary environment, is an excellent communicator, is self-motivated, and has a track record of excellence in designing and executing in vivo pharmacology experiments, preferably in the area of cancer. The position will be for a two year term, with review for potential permanent opportunities possible at eighteen months.
- Contribute to the development of Merrimack’s pipeline by establishing robust pre-clinical in vivo models to test new cancer therapies
- Perform efficacy, PK, PD, dose finding and toxicology studies
- Design experiments in collaboration with project team(s)
- Collaborate with multiple scientific teams to design and execute experiments that identify mechanisms of action and pharmacodynamic effects of candidate molecules in both cancer-cell and immune-cell contexts
- Engage colleagues in cross-disciplinary scientific discussion, present scientific data to internal and external audiences in accordance with Merrimack’s publication policy
- Stay abreast of relevant scientific literature
- Ph.D. in pharmaceutical sciences and other relevant disciplines such as immunology or physiology with a minimum of 1 year of relevant experience
- Strong knowledge of scientific principles and concepts with understanding of context for proper application in the following:
- Cancer biology and immunology
- Tissue culture and cell biology assays such as – Immunoprecipitation, Western blot, PCR, RT-PCR, Flow cytometry, ELISA, microscopy
- Handling of in vivo tumor models and tissue extraction
- Extensive in vivo experience, as this role will primarily involve in vivo pharmacological data generation
- Competence in rodent handling, including both human xenograft and syngeneic tumor models, and various routes of drug delivery are essential
- Competence in running PK/PD, efficacy and tolerability studies in murine models of cancer.
- A strong publication record, including a first author publication, is preferred
- Excellent written and oral communication skills
- Passion for developing new therapies that improve the treatment of cancer.