$100K — $150K *
The Research Scientist will be primarily responsible for designing and executing experiments using primary human immune cells and recombinant systems in vitro, as well as collaborating on in vitro and in vivo studies executed through CROs and will be based at our Lexington, MA, USA site. In this lab-based role, he or she will be a core scientific leader on the team tasked with interrogating mechanisms of action of Bicycle’s novel therapeutics and their uses in cancer biology.
We are looking for an independent and motivated scientist to conduct fast-paced science that contributes to the discovery and development of novel cancer therapies.
This role will be lab-based, but with opportunity to learn and grow through exposure and experience. The successful applicant will have a strong scientific background with a deep mechanistic understanding of cancer immunology, ideally focused on innate aspects of the anti-tumor immune response. He/she will also have expert laboratory skills in isolation and characterization of human immune cells, extensive practical and theoretical knowledge of flow cytometry, and design and execution of complex cell culture functional models of immunity. Experience with high-dimensional profiling of tumors at the protein, RNA, and genetic level to inform translational and clinical development is highly desired. Ability to conceive of, execute on, and write about cutting-edge science is essential, and will be evident as a record of publication in high-quality journals. In addition, experience with any of the following would be considered a plus: gene expression profiling, extracellular and intracellular signaling pathways, imaging by IHC and fluoresence microscopy, or methods in functional immunology.
The research scientist will work as part of the immuno-oncology laboratory team to develop and execute a workplan that is aligned with the program and portfolio strategy. This individual will be expected to be a “player/coach”, ie one who can flexibly alternate between executing independently and teaching techniques and providing guidance to peers. He/she will also closely interact with the UK-based Bicycle platform and Discovery teams as well as the global Chemistry and Translational Sciences teams for project-centric activities and for data and progress review.
Key Skills and Competencies
• PhD, with or without postdoctoral experience, constituting 6-8 years of industry or academic experience in cancer immunology, immuno-oncology, and/or translational oncology
• Expert knowledge in cancer immunology and ability to independently design and execute well-controlled experiments to reject or further scientific hypotheses
• Self-motivated and able to prioritize experiments and assignments to align with project objectives. Under supervision, may lead well-defined activities to achieve a project or corporate goal
• Ability to conduct research independently and manage multiple tasks in parallel, while being able to adapt individual contributions to help team achieve corporate goals
• Identifies and implements innovation to solve complex project-related problems. Demonstrates creativity and ingenuity in resolving obstacles to success
• Ability to analyze data independently, present experimental outcomes with scientific integrity, and interpret data to drive company decision-making and scientific narrative
• Team player who collaborates and communicates effectively in team environment. Comfort sharing knowledge with wider company team and, as appropriate, report work to the scientific or industry community
• Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment
Valid through: 8/13/2020
$200K — $250K
38 days ago