Bioinformatics Scientist – Cell Free DNA in Menlo Park, CA

$80K - $100K(Ladders Estimates)

Personalis   •  

Menlo Park, CA 94025

Industry: Pharmaceuticals & Biotech


Not Specified years

Posted 53 days ago

Personalis, Inc. is a dynamic venture-backed company founded out of Stanford pioneering precision medicine by developing, cutting-edge NGS genomic solutions for immuno-oncology, cancer, and inherited disease. Based in Menlo Park, CA, Personalis' patented ACE platform (Accuracy and Content Enhanced) provides an integrated, innovative, high accuracy technological solution from NGS sequencing to interpretation for precision medicine applications. The ACE Platform forms the technological basis for enabling Personalis' leading products for immuno-oncology, cancer diagnostics, and inherited disease.

You will work with a world-class, dynamic team of bioinformatics scientists, software engineers, laboratory scientists, assay developers, product managers, and clinicians applying our cutting-edge cancer and immuno-oncology solutions to plan, manage, analyze, and interpret impactful collaborative R&D projects. You will be part of a team focused on development of the latest methods for analyzing genomics data, building analysis pipelines and algorithms, and validating tools for immuno-oncology, neoantigens, and cancer. Your work will contribute to a new generation of genomics based precision medicine products in immuno-oncology and cancer clinical trials, diagnostics, and therapeutics being used by pharma, biotech, hospitals and clinicians.


  • Develop components of innovative cancer and immuno-oncology products, focusing on cfDNA/RNA and ctDNA applications
  • Design and develop tools for high accuracy, comprehensive somatic variant detection from cell free DNA and RNA sequencing
  • Develop methods for genomics based characterization of immuno-modulators and biomarkers for immuno-therapy
  • Extrapolate collaborative findings, identifying new product applications, new product opportunities, and biomarkers for cancer treatment that will influence product development
  • Work cross-functionally to translate findings into actively developed cutting-edge products
  • Design and implement validation strategies for genomics analysis tools and pipelines
  • Publish results and present at conferences in the area of cancer and immuno-oncology


  • Advanced degree (PhD) in bioinformatics, genomics, or a related field is required
  • Experience with genomic analysis of NGS based cell free DNA or RNA assays is required
  • Experience in cancer genomics is required
  • Experience in immuno-oncology is a plus
  • Experience developing bioinformatics pipelines and tools for NGS is a plus
  • Knowledge of neoantigens, immune checkpoints, tumor microenvironment, and tumor escape mechanisms is a plus
  • Experience with cancer genomics software: Mutect, Varscan2, etc. is required
  • Experience of cancer variant detection – Small variants, fusions, CNAs, etc.
  • Experience with standard genomics software: BWA, GATK, SAMTools, etc is a plus
  • Familiarity with cancer databases: Cosmic, TCGA, etc.

Valid Through: 2019-10-18