Associate Scientist, Analytical Development at TCR2 Therapeutics Inc. in Cambridge, MA

At TCR² Therapeutics Inc, our inclusive and diverse team is passionate about curing cancer. We are a clinical-stage immunotherapy company pioneering the development of novel T cell therapies. Our two lead cell product candidates are being studied in Phase 1/2 trials: TC-210 for solid tumors and TC-110 for hematological malignancies. Our research efforts focus on broadening our pipeline with a series of next-generation enhancements that may further improve clinical outcomes. We are headquartered in Cambridge, Massachusetts and have a clinical manufacturing facility in Stevenage, UK. This role is located in Cambridge, Massachusetts.

We are looking for an Associate Scientist to develop analytical bioassays and provide analytical understanding of T Cell and Lentiviral Vector characteristics. You will report to our head of Analytical Development and work closely with the T Cell and Vector Process Development teams.

Your primary responsibilities will include design and execution of studies for method development and product attribute understanding, authorship of technical protocols and reports, and execution of experiments. Additional activities could include evaluation of new technologies, and support of the technology transfer to either our manufacturing group located in the United Kingdom or CMOs. The position represents an excellent opportunity for career development, working closely with experienced scientists in a fast-paced and highly collaborative environment.

Responsibilities:

• Execute analytical methods to support assay development and product understanding for lentiviral vectors and T Cells.
• Design experiments, assist with data analysis, interpretation and troubleshooting and write corresponding technical reports for method development and product understanding studies.
• Write protocols and operating procedures for internal and/or technology transfer use.
• Work closely and effectively with our internal manufacturing group and/or CMOs for technology transfer and support.
• This is a hands-on position requiring execution of laboratory experiments.

Requirements:

• M.S. in biochemistry, chemical engineering, or related discipline with 4+ years relevant industry experience, or B.S. with 6+ years relevant industry experience. Industry experience is required for this position.
• Experience with analytical assay development required, with emphasis on cell and plate-based assays, including qPCR, ddPCR and/or ELISA.
• Experience with method qualification and/or validation a plus.
• Experience with flow cytometry, mammalian cell culture, and/or viral vectors a plus.
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures is desirable.
• Outstanding critical thinking and organizational skills, leadership, and attention to detail.
• Team-based candidate interested in a fast-paced, exciting, start-up environment!