Reporting to Director, Translational Medicine, the incumbent will be part of the translational group based in Summit NJ and will manage the scientific and preclinical laboratory component of multiple late stage hematology programs (phase 2 and beyond). Key responsibilities of this role are to serve as a key scientific lead for the preclinical support of asset programs through mechanism of action-based studies, differentiation from standard of care molecules, combination rationale and resistance mechanisms. He/She will work with translational scientists, disease leaders within translational medicine and thematic research centers in early development within the company. In addition, guidance of laboratory scientists to generate data in support of clinical development decisions will be required.
- Leads a group of scientists who execute the preclinical/laboratory support component of late stage BMS portfolio of compounds to support annual goals and objectives for the Heme translational medicine group (for internal /external, collaborations, compound specific plans etc).
- Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation
- Report directly to the head of the laboratory and manage laboratory scientists to integrate clinical questions into lab-based translational research internally and externally
- Interfaces with early development scientist to ensure seamless flow of information for assets which are entering the remit of translational medicine
- Manages and supervises a portfolio of preclinical collaborations across the pipeline compounds for clinical assets
- Assists in managing key strategic and/o
- r collaborative projects along with TM scientists
- Communicates regularly and prepares and makes presentations within the department, externally and to senior management as required
- Assists in developing and maintaining group budget and workforce plan
- PhD or MD/PhD with at least 10 years of relevant work experience. Experience including drug development in an industry setting, especially hematology indications is a plus.
- Strong publication record and track record in large and/or small companies, leading innovative efforts within the laboratory setting to achieve defined goals and support clinical development
- Excellent communication, managerial and scientific qualities are expected
- Ability to interact effectively across boundaries using influencing and relationship building skills.
- Competence in analysis and solving of problems, and the ability to prioritize and make tradeoffs to achieve goals.
- In-depth understanding of cancer biology (hematology a plus), clinical landscape, evolving technologies, competitive scenario
- Good understanding of drug development process in an industry setting with clear examples of success
- Understanding of late-stage drug and translational development process
- Ability to work with disease teams/experts to develop preclinical strategies to support clinical development and life cycle management
- Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications/reviews, disease strategies, mechanism slides, regulatory submissions, and strategic communications
- Proven scientific/project leadership expertise (working in teams, managing collaborations, people/projects)
- Basic understanding of IP, contracting terms and provisions
- A problem solver who creatively and knowledgeably transcends departmental function to act as a resource to entire research effort and senior managers in development.
- Identifies issues early and proposes innovative solutions.
- Communicates within the larger organization and external community.
- Provides expert guidance to multi-disciplinary teams and senior management.
- A leader whose scope of influence stretches across the company
- A leader who influences external scientific community.