Associate Director/Director, Translational Biology

Xencor   •  

San Diego, CA

Industry: Pharmaceuticals & Biotech

  •  

5 - 7 years

Posted 56 days ago

Job Duties include:

The Director/Associate Director, Translational Biology, acts as an independent scientist responsible for coordinating the analysis of genomics/transcriptomics/immunobiological data for preclinical studies and clinical studies. This person interacts with all members of the Translational Biology, Biometrics, Pre-Clinical and Clinical Development teams, and is accountable for the oversight and quality of analysis of immunobiological data (flow cytometry/multiplex immunofluorescence/cytokines) for clinical samples and genomics/transcriptomics data for pre-clinical science and clinical samples. Responsibilities may include some or all of the following:

•Plan, implement and manage biomarker projects with outside laboratories

•Champion analysis of genomics/transcriptomics for tumor biopsies and peripheral blood samples

•Participate with preclinical projects that require genomic/transcriptomic analysis of cultured cells or tissues/blood from animal models

•Lead contact on high dimensional data sets, e.g., transcriptomics of clinical trials

•Ensure that clinical biomarker data is scientifically rigorous and supports clinical development

•Manage a shared biostatistician with expertise in programming for high dimensional data sets, e.g., transcriptomics/genomics data Present pre-clinical data and the relevant literature at internal meetings

•Effectively manage projects as part of a multidisciplinary team

•Contribute to publications and presentations

•Represent supported projects at scientific conferences

•Leads interactions with investigators and cooperative groups

•Attends 3-4 scientific meeting or off-site meetings per year

•Other duties as assigned

•Deep understanding of complex cellular signaling pathways

•Data review, writing and interpretation

•Ability to work effectively with a cross-functional study team

•Ability to manage multiple (3-5) projects simultaneously, set and meet deadlines

•Ability to analyze complex flow cytometric data, transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence.

•Excellent oral and written communication skills

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that ae required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Qualifications/Requirements:

•Advanced Clinical/Science Degree (e.g. PharmD, PhD, Postdoctoral)

•Experience in pre-clinical/translational drug discovery, demonstrated strong achievements in academic and industry settings

•Minimum 5 years pre-clinical development experience in the pharmaceutical or biotechnology industry, 2 years may be sufficient for candidates with translational postdoctoral experience

•Knowledge of international regulations pertinent to current clinical development (eg ICH, FDA, EMA)

•Ability to analyze complex flow cytometric data (FloJo), transcriptomics (including Nanostring and RNAseq) and multiplex immunofluorescence

•Understanding of immunobiology and eagerness to work with clinical immunoncology data

•Highly advanced oral, writing and presentations skills

•Organized and able to set/meet deadlines

•Ability to work collaboratively in a team of people with different backgrounds and seniority levels