$100K — $150K *
Mirati Therapeutics (NASDAQ: MRTX) is a San Diego-based clinical-stage biotechnology company dedicated to advancing novel therapeutics that extend the lives of patients by directly addressing the genetic and immunological drivers of cancer. Mirati is developing Sitravatinib, designed to selectively target a spectrum of tyrosine kinases implicated in both tumor growth and the suppression of immune responses to tumors. Sitravatinib has demonstrated durable responses in lung cancer patients whose cancer has progressed despite treatment with checkpoint inhibitors - an area of significant unmet medical need. Sitravatinib is being evaluated in multiple clinical trials to treat patients who are refractory to prior immune checkpoint inhibitor therapy, including a potentially registration-enabling Phase 3 trial of Sitravatinib in combination with a checkpoint inhibitor in non-small cell lung cancer (NSCLC) that is currently enrolling patients.
Mirati is also developing novel direct inhibitors of KRAS mutations including MRTX849, a potent and selective inhibitor of KRAS G12C. This historically difficult to drug target is present in approximately 14% of NSCLC adenocarcinomas, 4% of colorectal cancer as well as smaller percentages of several other difficult-to-treat cancers. MRTX849 is being evaluated in a Phase 1/2 clinical trial as a treatment for patients with KRAS G12C-positive tumors. Our research on G12C has led to breakthroughs in targeting other KRAS mutations including G12D which drives tumor growth in more patients than G12C and includes pancreatic, colorectal and other types of cancer.
Who are we: Our mission is to discover, design, and deliver breakthrough therapies to transform the lives of cancer patients and their loved ones. We have built a culture fueled by accountability, urgency, collaboration and open-mindedness, and have established ourselves as an innovator within our industry. As we grow, we are looking to build diverse teams, with skilled individuals that are passionate about their work.
Why join us? Reporting directly to the Senior Director, Quality Assurance, the Associate Director, Analytical Quality Assurance will be responsible for the quality oversight and management of all GMP-analytical related activities, the quality management of contracted testing vendors, and strategies to advance overall company quality and compliance. This is both a hands-on and strategic quality assurance role for a small, emerging company in the targeted oncology therapeutic space with clinical assets in early and registrational phase development (based on an FDA Accelerated Approval timeframe). This key position requires a team player with a highly motivated attitude that will promote and cultivate cross-functional area support within the company to achieve and maintain the required levels of standards of quality and compliance, appropriate for the Mirati company GxP paradigm in balance with Mirati external GMP vendors. Your Responsibilities:
What is Required:
Valid through: 9/4/2020
$200K — $250K + stock options, etc.