Texas Medical Center (TMC) is a medical district and neighborhood in south-central Houston, Texas, immediately south of the Museum District and west of Texas State Highway 288. Over sixty medical institutions, largely concentrated in a triangular area between Brays Bayou, Rice University, and Hermann Park, are members of the Texas Medical Center Corporation?a non-profit umbrella organization?which constitutes the largest medical complex in the world. The TMC performs the most heart surgeries in the world, conducts the largest cancer research center outside of the National Cancer Institute, and conducts the largest pediatric care facility in the world. The TMC employs over 106,000 people, hosts 10 million patient encounters annually, and has a gross domestic product of $25 billion.