The Oklahoma Medical Research Foundation (OMRF), located in Oklahoma City, Oklahoma, is an independent, nonprofit biomedical research institute. Established in 1946, OMRF is dedicated to understanding and developing more effective treatments for human disease. Stephen M. Prescott serves as president of OMRF, which employs more than 500 scientific and administrative staff members. OMRF’s scientists, who include a member of the National Academy of Sciences, hold more than 700 U.S. and international patents and have spun off 11 biotech companies. Discoveries at OMRF led to Xigris, the first FDA-approved drug for the treatment of severe sepsis, and Ceprotin, a therapy for people suffering from a rare and life-threatening blood disorder known as protein C deficiency. Research at OMRF also identified the enzyme believed responsible for Alzheimer’s disease and laid the groundwork for OncoVue, a breast cancer risk assessment test. OMRF was chartered in 1946. The next year, Oklahoma Gov. Roy J. Turner launched a fund drive for OMRF that spanned all 77 of Oklahoma’s counties. By May 1949, 7,000 Oklahomans had donated and pledged $2.35 million, and construction of OMRF began.