The Barbara Ann Karmanos Cancer Institute, headquartered in Detroit, is the largest cancer research and provider network in Michigan and has 14 treatment locations. It is one of 47 National Cancer Institute-designated comprehensive cancer treatment and research centers in the United States. Affiliated to Wayne State University School of Medicine, the institute has 1,200 staff members, including 300 doctors, and 100 researchers. The staff treats approximately 12,000 patients each year and operates with a budget of $260 million. It conducts 800 cancer-specific scientific investigations programs and clinical trials each year. The institute has a Phase 1 program, one of 14 National Cancer Institute (NCI)-funded Phase 1 programs in the United States. Gerold Bepler is president and chief executive officer. Karmanos began as the Detroit Institute for Cancer Research in 1943 and was later named the Michigan Cancer Foundation, encompassing the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit and the cancer programs of the Detroit Medical Center and Wayne State University. In 1995, the cancer center was named after Barbara Ann Karmanos, the late wife of Peter Karmanos Jr., former chairman and chief executive officer of Compuware Corporation. Barbara Ann Karmanos succumbed to breast cancer at the age of 46. On October 30, 2013, Karmanos Cancer Institute and McLaren Health Care signed an agreement that created the largest cancer research and provider network in Michigan. The agreement was finalized in January 2014.