GenScript

GenScript

Employees:
1,300
Market Cap:
$15.2 billion
Revenue:
$115 million
Net Income:
$200 million

GenScript

Employees:
1,300
Market Cap:
$15.2 billion
Revenue:
$115 million
Net Income:
$200 million

Aug 21, 1:00 PM

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis: http://ow.ly/GksO30eyl7H. Results from a new study by Zhang et al. show that the Hippo pathway effector, Yap, promotes the diploid-polyploid conversion and polyploid cell growth via the Akt signaling and p300-mediated acetylation of Skp2. This in turn leads to cytosolic retention of Skp2 and differential regulation of p27 and FoxO1/3 stabilities. Dysregulated Hippo-Yap-Skp2 axis was also shown to be associated with human hepatocellular carcinomas. This discovery presents an alternative polyploid checkpoint, along with p53, for limiting the risk of genomic instability and tumorigenesis.

Aug 14, 1:00 PM

Heterosis in Amazon Butterflies: http://ow.ly/gUa730enHVN. In evolutionary biology, the interplay between local adaption typically kills the polymorphism due to the fixation of beneficial alleles. On the other hand, sexual selection can play a role in this phenomenon, but the interplay between these two forces were not well understood. Now, the research done by Mathieu Chouteau et al. on the mating behavior of Heliconius numata butterflies in Amazon sheds light on this process. Apparently in this unique butterfly the wing pattern diversity is maintained against predators because the mating happens between dissimilar forms. This discovery, which indicates that presence of heterozygote genotypes at a locus is beneficial for maintaining the diversity in local populations, is consistent with heterosis.

Aug 3, 1:00 PM

CRISPR precisely and safely repairs a disease gene in human embryos: http://ow.ly/1Dzx30e7XLS. Although the application of CRISPR-Cas9 for disease gene correction in human embryos has been reported before, the off-target side effect is still a huge concern remaining exploration. Now, an international research team utilized CRISPR-Cas9 to fix the MYBPC3 gene mutation in human embryos, meanwhile, they invested the efficiency, accuracy and safety. The encouraging results revealed that CRISPR can efficiently yield fixed homozygous embryos without off-target mutation.

Aug 2, 3:30 PM

Do you like to mix and match? Well, so do we! Mix and Match our Secondary Antibodies (http://ow.ly/g3Bb30e5X0C) and Protein Standards (http://ow.ly/qP8C30e5X2y). Enter Promo Code ABPMQ317 to get 25% OFF when you purchase. Promotion valid until 9/30/17.