Oct 24 at 1:14 AM
ZATT Protein Repairs DNA Damage Caused by Cancer Treatment: http://ow.ly/rr8r30g5biZ. NIH researchers uncovered for the first time the underlying mechanism behind cellular recovery after severe DNA damage induced by chemotherapy. A few anti-cancer drugs are known to trap the topoisomerase 2 (TOP2)-DNA complex (TOP2cc), which is an intermediate in TOP2 processing of DNA topology. This in turn conceals the TOP2-induced DNA cut, and results in the accumulation of DNA damage and cell death. In this study, it was revealed that ZATT, a SUMO ligase, could repair such DNA damages by promoting the removal of TOP2cc through a ZATT-Tyrosyl DNA phosphodiesterase 2-catalyzed and SUMO2-modulated pathway. This finding is useful in developing not only new drugs to lower tumor adaptation to chemotherapy, but also more effective chemotherapeutic drugs.