Conducting in vivo and ex vivo experiments on animal models of diseases, including development and induction of disease models, delivery of candidate drug regimens, making clinical observations, and harvesting samples for the evaluation of drug levels, histology, and molecular endpoints.
The successful candidate will join a dynamic, multi-disciplinary team of in vivo biologists in IO, playing a key role in the development and monitoring of in vivo models of cancer and the use of those models to evaluate new immunotherapeutic strategies and drug candidates.
Participate in the design, development, characterization, implementation and validation of relevant immuno-oncology-related in vivo models including subcutaneous and orthotopic models for identifying and profiling the biologic effects of immunotherapeutic strategies and drug candidates.
Works closely with cross-functional team of engineers, rubber technologists, analytical scientists to test new formulations, prototype, develop technology or conduct complex non-standard procedures and tests.
Ensure data quality throughout all stages of acquisition and processing, including such areas as data sourcing/collection, ground truth generation, normalization, transformation, cross-lingual alignment/mapping, etc.
A strong background in mammalian genetics and genomic editing techniques is desired. Design and execute independent laboratory research projects aimed at developing novel human iPSC models of human diseases.
Manage and implement medical research activities and coordinates strategies essential to the successful administration of research projects; carry out translational research for development of disease-related biomarkers.
Responsible for designing and performing a broad range of bioanalytical and biomarker method development, validation, and sample testing for both large and small molecules to support Research, Non-clinical, Clinical and Commercial Development programs for rare diseases in a variety of therapeutic indications.
The successful applicant will carry out the downstream processing of recombinant proteins from microbial expression systems with the goal being to develop efficient, scalable and robust purification procedures that produce proteins of sufficient potency, purity and quantity to supply toxicology and clinical studies.
Conduct critical evaluation of analytical testing procedure, method performance matrix and testing results across global testing network, generate gap analysis reports and provide gap remediation recommendation.
Responsible for the application of cutting edge science to the functional and chemical validation of new cancer targets, and will provide molecular pharmacology support for the chemical optimization of molecular therapeutics.