Contribute to design and execution of computational strategies such as multi-meric protein complex modeling, protein design and protein conformational changes using homology/protein modeling, molecular dynamics/Monte Carlo simulations, coarse-grained modeling, allosteric and cryptic site identification.
The successful candidate will lead a small group of scientists that develops methodologies for target deconvolution of small molecule hits emerging from phenotypic screens and execute projects to identify mechanism of action of such compounds.
This position resides in the Process Development group within Drug Product Design. The primary responsibility is to provide drug product formulation and manufacturing process design expertise in order to deliver the R & D portfolio, including hands-on support for dosage form development activities.
The successful candidate will join the department of structural and molecular sciences (sms), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, nmr, biophysics, protein crystallography and cryo-em.
The candidate will be responsible for maintaining proficiency in a breadth of analytical methodologies including HPLC/UPLC, SDS-PAGE, iCE, and CE and applying these methods to a broad range of biotherapeutics for early and late stage products.
The Senior PV Scientist will provide oversight to any contracted vendors involved in the preparation (e.g., document management and authoring) of assigned aggregate safety reports. The Senior PV Scientist will have oversight for the quality of all assigned aggregate reports including those prepared internally or through contracted vendors.
The primary responsibility is to provide drug product formulation and manufacturing process design expertise in order to deliver the r & d portfolio, including hands-on support for dosage form development activities.
The successful applicant will interface with domain area experts in computational sciences, medicinal chemistry, structural biology, analytical chemistry, PDM and primary pharmacology groups and will be accountable for developing and delivering computational solutions for key medicine design project team endpoints.
Troubleshoot hard to synthesize RNA constructs and devise novel process solutions to enable production; develop analytical methods to advance mRNA construct analysis and production process performance.
The successful candidate will participate in the statistical design and analysis of human genetic studies including common variant association and rare variant association studies from next - generation sequencing and chip - based studies.
Work closely with other Pearl River or Cambridge Functional Genomics lab personnel, and maintain close and productive interactions with the Functional Genomics lab personnel based in Pearl River or Cambridge.
This individual will utilize the entire suite of protein LC-MS/MS detection systems to develop the most reliable measurements for endogenous proteins critical for derisking pathology and investigative toxicology projects.
You will be responsible for planning and executing developability/device ability assessments, collaborating with colleagues in discovery, protein engineering, analytics, process development, and project management. Research activities will be focused in the areas of high throughput credentialing of therapeutic candidates and miniaturization of biophysical assays.
The position will involve use of innovative and modern techniques to develop and characterize dosage forms with appropriate stability profiles and develop associated manufacturing processes to meet project needs.