This individual will work across the Hematology and Oncology Therapeutic Areas (TA) and in collaboration with the Head of the I/O Thematic Centers of Excellence within Early Drug development, Translational Research and Business Development.
Design and develop downstream protein purification process and perform process optimization of large molecule/recombinant proteins from traditional cell culture, microbial fermentation, or new and unconventional bioprocesses, including second generation therapeutic antibodies, antibody-drug conjugates, bi-specific antibodies and fusion proteins.
The position is focused on optimization for traffic management and network resource utilization in SDN-enabled networks. Example tasks may include quantification of SDN network benefits, network topology designs and evaluation, scalable controller algorithms for traffic engineering and capacity management in an SDN and multi-layer environment, and recommendations for placement of SDN controllers for cost-effective and reliable service.
Performing key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.
Working with a range of exciting new technologies and data sources, the individual will lead and participate in collaborative projects together with universities, health authorities, health technology providers and industry.
The successful candidate will be responsible for technical planning and execution of formulation development, drug product process development, primary packaging development, technology transfer to CMOs, scale-up, characterization and validation activities for protein therapeutics programs.
In this role, the selected candidate will design and execution of research investigations consistent with sound, robust scientific investigations that meet international standards and are defensible in front of the scientific community.
This Sr. Scientist position in Biologics Upstream Process Development will focus initially on a bispecific program, and be responsible for the development of scalable cell culture processes, for research and Tox material production, and for scale up and transfer of processes to GMP facilities for clinical manufacturing, towards IND submission by the year end of 2017.