Troubleshoot hard to synthesize RNA constructs and devise novel process solutions to enable production; develop analytical methods to advance mRNA construct analysis and production process performance.
The candidate will be responsible for maintaining proficiency in a breadth of analytical methodologies including HPLC / UPLC, SDS - PAGE, iCE, and CE and applying these methods to a broad range of biotherapeutics for early and late stage products.
Collaboratively plan and execute in-depth analyses using techniques such as ellipsometry, DSC, TGA, FTIR, Raman, SEM, XPS, TOF-SIMS, AFM, high resolution spectroscopy and microscopy to characterize dimensions at the interface between assay chemistry and substrate materials.
In this role, you will identifies, strategizes, prioritizes and manages own activities to bring agile resolution to a variety of problems of moderate scope and complexity to support company products in alignment with organizational objectives.
The position will work with a cross-functional team, delivering analytical projects related to customer engagement, segmentation, targeting, customer life time value, partnering with internal and external clients to solve important health care challenges.
Develop and perform cell-based assays to assess the impact of small molecule inhibitors, shRNA, and/or CRISPR-mediated knockouts to validate targets in anti-tumor immunity as well as identify key pathway-based biomarkers.
Develop and perform cell-based assays to assess the impact of small molecule modulators, shRNA, and/or CRISPR-mediated knockout on cancer and immune cell proliferation/differentiation as well as pathway-based biomarkers.
Design, conduct, analyse, and report data gathered from qualitative and quantitative research techniques including key-stroke level modelling (KLM), usability testing, contextual inquiry/field studies, surveys, interviews, heuristic evaluations, focus groups, card sorts, ethnography and persona development, and rapid iterative testing within an Agile environment.