A strong background in mammalian genetics and genomic editing techniques is desired. Design and execute independent laboratory research projects aimed at developing novel human iPSC models of human diseases.
Works closely with cross-functional team of engineers, rubber technologists, analytical scientists to test new formulations, prototype, develop technology or conduct complex non-standard procedures and tests.
The successful applicant will carry out the downstream processing of recombinant proteins from microbial expression systems with the goal being to develop efficient, scalable and robust purification procedures that produce proteins of sufficient potency, purity and quantity to supply toxicology and clinical studies.
Ensure data quality throughout all stages of acquisition and processing, including such areas as data sourcing/collection, ground truth generation, normalization, transformation, cross-lingual alignment/mapping, etc.
Be part of a team who is building a platform for reporting and analytics and moving towards advanced analytics plus predictive modelling; finding innovative solutions to diverse business problems using advanced statistical methods.
The successful candidate will join a dynamic, multi-disciplinary team of in vivo biologists in IO, playing a key role in the development and monitoring of in vivo models of cancer and the use of those models to evaluate new immunotherapeutic strategies and drug candidates.
Responsible for designing and performing a broad range of bioanalytical and biomarker method development, validation, and sample testing for both large and small molecules to support Research, Non-clinical, Clinical and Commercial Development programs for rare diseases in a variety of therapeutic indications.
The successful candidate will develop and validate animal models relevant to human metabolic disorders, lead and coordinate in vivo genetic and pharmacology studies, conduct mechanistic investigations using tissues and primary cells, prepare study report and communicate with cross function team. T
Conducting in vivo and ex vivo experiments on animal models of diseases, including development and induction of disease models, delivery of candidate drug regimens, making clinical observations, and harvesting samples for the evaluation of drug levels, histology, and molecular endpoints.