This position resides in the Process Development group within Drug Product Design. The primary responsibility is to provide drug product formulation and manufacturing process design expertise in order to deliver the R & D portfolio, including hands-on support for dosage form development activities.
The primary responsibility is to provide drug product formulation and manufacturing process design expertise in order to deliver the r & d portfolio, including hands-on support for dosage form development activities.
The successful candidate will join the department of structural and molecular sciences (sms), a multidisciplinary group with established expertise in molecular biology, protein biochemistry, protein mass spectrometry, enzymology, nmr, biophysics, protein crystallography and cryo-em.
The successful applicant will interface with domain area experts in computational sciences, medicinal chemistry, structural biology, analytical chemistry, PDM and primary pharmacology groups and will be accountable for developing and delivering computational solutions for key medicine design project team endpoints.
Contribute to design and execution of computational strategies such as multi-meric protein complex modeling, protein design and protein conformational changes using homology/protein modeling, molecular dynamics/Monte Carlo simulations, coarse-grained modeling, allosteric and cryptic site identification.
As a Senior Scientist - Protein Crystallography, you will apply expert knowledge to determine the atomic structures of novel drug target proteins and protein-ligand complexes by protein crystallographic methods and extract novel and relevant structural insights to drive drug discovery efforts.
In this role, you will provides technical thought leadership in security and trustworthy solutions to the full range of UTC products and programs. Our programs involve both practical technology development as well as innovative scientific research to advance the state-of-the-art methodologies and practices.
The Senior Scientist will be part of the Biopharmaceutics Group and will provide guidance and recommendations on biopharmaceutics aspects for drug products during their entire lifecycle from early development to post marketing changes.
Utilizes appropriate predictive models and Science of Scale approaches to understand mechanical and physico-chemical characteristics of pharmaceutical compounds and formulations/process to drive decisions and assess drug product performance.
This laboratory scientist will provide high quality in vitro plate-based pharmacology data to project teams to enable rapid decision making in support of the Worldwide Research and Development portfolio.
This laboratory scientist will independently provide high quality in vitro plate-based pharmacology data to project teams to enable rapid decision making in support of the Worldwide Research and Development portfolio.`