The successful candidate will lead a small group of scientists that develops methodologies for target deconvolution of small molecule hits emerging from phenotypic screens and execute projects to identify mechanism of action of such compounds.
The candidate will be responsible for maintaining proficiency in a breadth of analytical methodologies including HPLC / UPLC, SDS - PAGE, iCE, and CE and applying these methods to a broad range of biotherapeutics for early and late stage products.
The position will involve use of innovative and modern techniques to develop and characterize dosage forms with appropriate stability profiles and develop associated manufacturing processes to meet project needs.
Troubleshoot hard to synthesize RNA constructs and devise novel process solutions to enable production; develop analytical methods to advance mRNA construct analysis and production process performance.
This individual will utilize the entire suite of protein LC-MS/MS detection systems to develop the most reliable measurements for endogenous proteins critical for derisking pathology and investigative toxicology projects.
The Senior PV Scientist will provide oversight to any contracted vendors involved in the preparation (e.g., document management and authoring) of assigned aggregate safety reports. The Senior PV Scientist will have oversight for the quality of all assigned aggregate reports including those prepared internally or through contracted vendors.
In this role, you will identifies, strategizes, prioritizes and manages own activities to bring agile resolution to a variety of problems of moderate scope and complexity to support company products in alignment with organizational objectives.
The successful candidate will participate in the statistical design and analysis of human genetic studies including common variant association and rare variant association studies from next - generation sequencing and chip - based studies.
The candidate will be responsible for maintaining proficiency in a breadth of analytical methodologies including HPLC/UPLC, SDS-PAGE, iCE, and CE and applying these methods to a broad range of biotherapeutics for early and late stage products.
Collaboratively plan and execute in-depth analyses using techniques such as ellipsometry, DSC, TGA, FTIR, Raman, SEM, XPS, TOF-SIMS, AFM, high resolution spectroscopy and microscopy to characterize dimensions at the interface between assay chemistry and substrate materials.
Manage technical aspects of project and product cost against budget; reports and advises on recovery plans necessary to achieve budget targets; coordinate with team leaders and manufacturing to plan and execute transfer of products from design to production.